Table 1.
Characterisation of the different types of porous silicon particles after intravitreal injection
| Particle type | No. of eyes tested | Maximum vitreous residence time | Estimated vitreous half-life by ophthalmoscopy | Bio-microscopy* and indirect ophthalmoscopy | Intraocular pressure | Electroretinography | Pathology |
|---|---|---|---|---|---|---|---|
| Unmodified (fresh) | 3 | 4 weeks | 1 week | Normal at all checking points | Normal at 1, 2, 4 weeks | Normal at 4 weeks | Normal at 4 weeks |
| 5% dextrose | 3 | NA | NA | Normal at all checking points | Normal at 1, 2, 4 weeks | Normal at 4 weeks | Normal at 4 weeks |
| Hydrosilylated | 5 | .17 weeks | 16 weeks | Normal at all checking points | Normal at 1, 2, 4, 12, 17 weeks | Normal at 12, 17 weeks | Normal at 17 weeks |
| 5% dextrose | 5 | NA | NA | Normal at all checking points | Normal at 1, 2, 4, 12, 17 weeks | Normal at 12, 17 weeks | Normal at 17 weeks |
| Oxidised | 3 | 12 to .18 weeks | 5 weeks | Normal at all checking points | Normal at 1, 2, 4, 12, 18 weeks | Normal at 12, 18 weeks | Normal at 18 weeks |
| 5% dextrose | 3 | NA | NA | Normal at all checking points | Normal at 1, 2, 4, 12, 18 weeks | Normal at 12, 18 weeks | Normal at 18 weeks |
| Oxidised at high temperature | 3 | 10 to 12 months | 8 weeks | Normal at all checking points | Normal at 2, 6, 16, 24, 40, 52 weeks | Normal at 16, 24, 40, 52 weeks | Normal at 12 months |
| 5% dextrose | 3 | NA | NA | Normal at all checking points | Normal at 2, 6, 16, 24, 40, 52 weeks | Normal at 16, 24, 40, 52 weeks | Normal at 12 months |
*
Slit-lamp examination of cornea, anterior chamber, lens, vitreous, and indirect ophthalmoscopy of fundus.