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. Author manuscript; available in PMC: 2010 Apr 1.
Published in final edited form as: Cancer. 2009 Apr 1;115(7):1498–1506. doi: 10.1002/cncr.24157

Table 1.

Association of COX-2 SNPs with OPL Risk Stratified by Patient Characteristics

Variables COX-2 −765G>C, rs20417
COX-2 exon 10 +837T>C, rs5275
COX-2 exon 10 −90C>T, rs68479
Case/Control OR (95% CI)* Case/Control OR (95% CI) Case/Control OR (95% CI)
P P P
Overall
WW** 97/90 Reference 70/50 Reference 131/132 Reference
WM+MM** 37/54 0.7 (0.41−1.20) 66/95 0.48 (0.28−0.80) 5/13 0.43 (0.14−1.33)
0.197 0.005 0.143
Age
Young WW 48/41 Reference 37/21 Reference 65/62 Reference
WM+MM 17/30 0.45 (0.19−1.05) 31/49 0.27 (0.12−0.61) 3/9 0.34 (0.08−1.41)
0.063 0.002 0.136
Old WW 49/49 Reference 33/29 Reference 66/70 Reference
WM+MM 20/24 0.79 (0.36−1.75) 35/46 0.68 (0.33−1.41) 2/4 0.49 (0.07−3.42)
0.567 0.301 0.473
Gender
Male WW 56/45 Reference 37/24 Reference 74/73 Reference
WM+MM 21/37 0.51 (0.24−1.07) 41/57 0.37 (0.17−0.78) 4/9 0.43 (0.11−1.68)
0.076 0.009 0.223
Female WW 41/45 Reference 33/26 Reference 57/59 Reference
WM+MM 16/17 1.00 (0.42−2.35) 25/38 0.47 (0.21−1.04) 1/4 0.37 (0.04−3.53)
0.998 0.062 0.385
Smoking status
Never WW 26/51 Reference 19/26 Reference 43/70 Reference
WM+MM 17/28 1.21 (0.55−2.66) 25/54 0.65 (0.30−1.42) 1/10 0.14 (0.2−1.17)
0.642 0.282 0.070
Ever WW 71/39 Reference 51/24 Reference 88/62 Reference
WM+MM 20/26 0.39 (0.18−0.84) 41/41 0.34 (0.16−0.71) 4/3 0.96 (0.18−5.03)
0.016 0.004 0.959
Alcohol consumption
Never WW 44/32 Reference 29/15 Reference 59/43 Reference
WM+MM 17/13 0.80 (0.31−2.10) 32/32 0.42 (0.16−1.08) 3/3 0.57 (0.09−3.53)
0.654 0.071 0.541
Ever WW 53/38 Reference 41/35 Reference 72/89 Reference
WM+MM 20/41 0.63 (0.31−1.29) 34/63 0.42 (0.21−0.84) 2/10 0.30 (0.06−1.60)
0.210 0.013 0.160

COX-2 indicates the cyclooxygenase-2 gene; OR, odds ratio; CI, confidence interval; WW, homozygous wild-type genotype; WM, heterozygous genotype; MM, homozygous variant genotype.

*

Adjusted for age, gender, ethnicity, smoking status, and pack-years for the overall analysis; adjusted for age, sex, ethnicity, and pack-years for the analysis that was stratified by smoking status; adjusted for age, sex, ethnicity, and smoking status for the analysis that was stratified by smoking level; adjusted for age, ethnicity, smoking status, and pack-years for the analysis that was stratified by sex; adjusted for sex, ethnicity, smoking status, and pack-years for the analysis that was stratified by age.

**

WW: homozygous wild-type genotype; WM: heterozygous genotype; MM: homozygous variant genotype.