Table 1.
Association of COX-2 SNPs with OPL Risk Stratified by Patient Characteristics
| Variables |
COX-2 −765G>C, rs20417 |
COX-2 exon 10 +837T>C, rs5275 |
COX-2 exon 10 −90C>T, rs68479 |
|||||
|---|---|---|---|---|---|---|---|---|
| Case/Control | OR (95% CI)* | Case/Control | OR (95% CI) | Case/Control | OR (95% CI) | |||
| P | P | P | ||||||
| Overall | ||||||||
| WW** | 97/90 | Reference | 70/50 | Reference | 131/132 | Reference | ||
| WM+MM** | 37/54 | 0.7 (0.41−1.20) | 66/95 | 0.48 (0.28−0.80) | 5/13 | 0.43 (0.14−1.33) | ||
| 0.197 | 0.005 | 0.143 | ||||||
| Age | ||||||||
| Young | WW | 48/41 | Reference | 37/21 | Reference | 65/62 | Reference | |
| WM+MM | 17/30 | 0.45 (0.19−1.05) | 31/49 | 0.27 (0.12−0.61) | 3/9 | 0.34 (0.08−1.41) | ||
| 0.063 | 0.002 | 0.136 | ||||||
| Old | WW | 49/49 | Reference | 33/29 | Reference | 66/70 | Reference | |
| WM+MM | 20/24 | 0.79 (0.36−1.75) | 35/46 | 0.68 (0.33−1.41) | 2/4 | 0.49 (0.07−3.42) | ||
| 0.567 | 0.301 | 0.473 | ||||||
| Gender | ||||||||
| Male | WW | 56/45 | Reference | 37/24 | Reference | 74/73 | Reference | |
| WM+MM | 21/37 | 0.51 (0.24−1.07) | 41/57 | 0.37 (0.17−0.78) | 4/9 | 0.43 (0.11−1.68) | ||
| 0.076 | 0.009 | 0.223 | ||||||
| Female | WW | 41/45 | Reference | 33/26 | Reference | 57/59 | Reference | |
| WM+MM | 16/17 | 1.00 (0.42−2.35) | 25/38 | 0.47 (0.21−1.04) | 1/4 | 0.37 (0.04−3.53) | ||
| 0.998 | 0.062 | 0.385 | ||||||
| Smoking status | ||||||||
| Never | WW | 26/51 | Reference | 19/26 | Reference | 43/70 | Reference | |
| WM+MM | 17/28 | 1.21 (0.55−2.66) | 25/54 | 0.65 (0.30−1.42) | 1/10 | 0.14 (0.2−1.17) | ||
| 0.642 | 0.282 | 0.070 | ||||||
| Ever | WW | 71/39 | Reference | 51/24 | Reference | 88/62 | Reference | |
| WM+MM | 20/26 | 0.39 (0.18−0.84) | 41/41 | 0.34 (0.16−0.71) | 4/3 | 0.96 (0.18−5.03) | ||
| 0.016 | 0.004 | 0.959 | ||||||
| Alcohol consumption | ||||||||
| Never | WW | 44/32 | Reference | 29/15 | Reference | 59/43 | Reference | |
| WM+MM | 17/13 | 0.80 (0.31−2.10) | 32/32 | 0.42 (0.16−1.08) | 3/3 | 0.57 (0.09−3.53) | ||
| 0.654 | 0.071 | 0.541 | ||||||
| Ever | WW | 53/38 | Reference | 41/35 | Reference | 72/89 | Reference | |
| WM+MM | 20/41 | 0.63 (0.31−1.29) | 34/63 | 0.42 (0.21−0.84) | 2/10 | 0.30 (0.06−1.60) | ||
| 0.210 | 0.013 | 0.160 | ||||||
COX-2 indicates the cyclooxygenase-2 gene; OR, odds ratio; CI, confidence interval; WW, homozygous wild-type genotype; WM, heterozygous genotype; MM, homozygous variant genotype.
Adjusted for age, gender, ethnicity, smoking status, and pack-years for the overall analysis; adjusted for age, sex, ethnicity, and pack-years for the analysis that was stratified by smoking status; adjusted for age, sex, ethnicity, and smoking status for the analysis that was stratified by smoking level; adjusted for age, ethnicity, smoking status, and pack-years for the analysis that was stratified by sex; adjusted for sex, ethnicity, smoking status, and pack-years for the analysis that was stratified by age.
WW: homozygous wild-type genotype; WM: heterozygous genotype; MM: homozygous variant genotype.