Table 2.
Association of COX-2 Haplotypes* and OPL Risk Stratified by Patient Characteristics
| Variables | H1 (WWW**) |
H2 (WMW) |
H3 (MMW) |
H4 (MMM) |
|||||
|---|---|---|---|---|---|---|---|---|---|
| Cases/Controls | OR (95% CI)# | Cases/Controls | OR (95% CI) | Cases/Controls | OR (95% CI) | Cases/Controls | OR (95% CI) | ||
| P | P | P | P | ||||||
| Overall | |||||||||
| 173/191 | Reference | 53/37 | 0.55 (0.33−0.93) | 47/32 | 0.62 (0.35−1.08) | 7/3 | 0.38 (0.09−1.60) | ||
| 0.027 | 0.093 | 0.187 | |||||||
| Age | |||||||||
| Young | 80/97 | Reference | 23/17 | 0.49 (0.22−1.09) | 26/14 | 0.33 (0.13−0.83) | 4/2 | 0.25 (0.04−1.47) | |
| 0.080 | 0.019 | 0.126 | |||||||
| Old | 93/94 | Reference | 30/20 | 0.65 (0.31−1.35) | 21/18 | 0.80 (0.36−1.80) | 3/1 | 0.49 (0.05−5.15) | |
| 0.247 | 0.590 | 0.555 | |||||||
| Gender | |||||||||
| Male | 90/106 | Reference | 29/26 | 0.58 (0.28−1.21) | 32/17 | 0.44 (0.20−0.96) | 3/3 | 0.55 (0.08−4.04) | |
| 0.145 | 0.040 | 0.58 | |||||||
| Female | 83/85 | Reference | 24/11 | 0.42 (0.18−0.99) | 15/15 | 0.84 (0.36−1.96) | 4/0 | N/A | |
| 0.047 | 0.681 | ||||||||
| Smoking status | |||||||||
| Never | 92/58 | Reference | 31/10 | 0.53 (0.24−1.15) | 24/16 | 1.07 (0.47−2.41) | 6/0 | N/A | |
| 0.108 | 0.874 | ||||||||
| Ever | 81/133 | Reference | 22/27 | 0.60 (0.29−1.24) | 22/16 | 0.37 (0.17−0.81) | 1/3 | 1.16 (0.10−13.88 ) | |
| 0.168 | 0.013 | 0.909 | |||||||
| Alcohol status | |||||||||
| Never | 56/85 | Reference | 21/18 | 0.39 (0.15−1.04) | 12/13 | 0.57 (0.20−1.63) | 2/3 | 0.54 (0.09−3.13) | |
| 0.059 | 0.294 | 0.493 | |||||||
| Ever | 117/106 | Reference | 32/19 | 0.55 (0.28−1.09) | 35/19 | 0.60 (0.29−1.22) | 5/0 | N/A | |
| 0.086 | 0.160 | ||||||||
Order of SNPs comprising COX-2 haplotype: −765G>C, exon 10 +837T>C, and exon 10 −90C>T.
W: wild-type allele, M: variant allele.
OR, odds ratio; CI, confidence interval; WW, homozygous wild-type genotype; WM, heterozygous genotype; MM, homozygous variant genotype.
Adjusted for age, gender, ethnicity, smoking status, and pack-years for the overall analysis; adjusted for age, sex, ethnicity, and pack-years for the analysis that was stratified by smoking status; adjusted for age, sex, ethnicity, and smoking status for the analysis that was stratified by smoking level; adjusted for age, ethnicity, smoking status, and pack-years for the analysis that was stratified by sex; and adjusted for sex, ethnicity, smoking status, and pack-years for the analysis that was stratified by age.
N/A: Not available.