Table 4.
Joint Effects between Genotypes and Smoking Status for OPLs
| Genotype | Exposure Status | Controls (%) | Cases (%) | Adjusted OR (95% CI)* | Pinteraction |
|---|---|---|---|---|---|
| Smoking status | |||||
| COX-2 −765G>C, rs20417 | |||||
| WM+MM | No | 28 (19.44) | 17 (12.69) | 1.00 (ref.) | |
| WM+MM | Yes | 26 (18.06) | 20 (14.93) | 1.29 (0.55−3.06) | |
| WW | No | 51 (35.42) | 26 (19.40) | 0.77 (0.35−1.68) | |
| WW | Yes | 39 (27.08) | 71 (52.99) | 2.99 (1.43−6.23) | 0.041 |
| COX-2 exon 10 +837T>C, rs5275 | |||||
| WM+MM | No | 54 (37.24) | 25 (18.38) | 1.00 (ref.) | |
| WM+MM | Yes | 41(28.28) | 41 (30.15) | 2.22 (1.15−4.29) | |
| WW | No | 26 (17.93) | 19 (13.97) | 1.53 (0.71−3.31) | |
| WW | Yes | 24 (16.55) | 51 (37.50) | 4.95 (2.48−9.91) | 0.465 |
| COX-2 exon 10 −90C>T, rs68479 | |||||
| WM+MM | No | 10 (6.90) | 1 (0.74) | 1.00 (ref.) | |
| WM+MM | Yes | 3 (2.07) | 4 (2.94) | 14.73 (1.12−192.90) | |
| WW | No | 70 (48.28) | 43 (31.62) | 6.24 (0.76−51.33) | |
| WW | Yes | 62 (42.76) | 88 (64.71) | 15.60 (1.91−127.63) | 0.184 |
OR indicates odds ratio; CI, confidence interval; COX-2, cyclooxygenase-2 gene; rs, reference single-nucleotide polymorphism; WM, heterozygous genotype; MM, homozygous variant genotype; WW, homozygous wild-type genotype.
*
Adjusted for gender and age.