Figure 1.

Effect of CLT on P. falciparum growth at two different stages of parasite development (clone A4). CLT was added to ring-stage synchronized cultures. [³H]Hypoxanthine was added either 15 min (ring trophozoites, R, ●) or 20 hr (mature-trophozoite stage, T, ○) after CLT. Parameter values for the concentration-response curves were determined as described in Table 1. The results were: young, ring-stage trophozoites, IC₅₀ = 1.24 ± 0.05 μM, b = 1.9 ± 0.1; mature trophozoites, IC₅₀ = 1.09 ± 0.03 μM, b = 8.2 ± 1.3.