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. Author manuscript; available in PMC: 2009 Apr 7.
Published in final edited form as: Biol Pharm Bull. 2008 Feb;31(2):231–234. doi: 10.1248/bpb.31.231

Table 1.

The Km, Vmax, and Clint (Vmax/Km) Values of Bupropion and Its Three Major Metabolites and Sertraline and Desmethylsertraline on ortho-Vanadate-Sensitive ATPase Activity in Expressed P-gp Membranea)

Km (μm) Vmax (nmol/mg/min) Clint: intrinsic clearance (min−1 × 10−3)
Verapamil 8.7 14.8 1.7
Sertralinc 4.7 7.7 1.6
Desmethylsertraline 6.5 9.3 1.4
Bupropion 2676 48.6 0.018
HB 318.2 10.0 0.03
TB 2066 19.5 0.01
EB 109.3 8.5 0.08
a)

Data were mean of duplicate determinations.