TABLE 1.
Effect of PLP-dependent enzyme inhibition and oxidative stress on the concentration of cytoplasmic glycine and serine1
All enzymes | GDC only | cSHMT | mSHMT | Oxidative stress2 | |
---|---|---|---|---|---|
% Change from normal | |||||
Glycine | 74 | 72 | 0 | 0 | −8 |
Serine | 7 | 7 | 0 | 0 | −1 |
Columns indicate which enzymes are inhibited.
The effect of oxidative stress alone was simulated by doubling [H2O2].