TABLE 2.

Effect of reducing the V_max of cSHMT and mSHMT on various steady-state reaction velocities and metabolite concentrations

	Reaction velocities					Concentrations
Relative Vmax	TS	MTHFR	GDC	5mTHF	CH2-THF	SAM	cGly1	cSer2
cSHMT only	% Change from normal
1 (normal)	0	0	0	0	0	0	0	0
0.5	−1	0	0	0	−2	−1	−1	0
0.1	−2	−1	1	−1	−4	−2	−1	0
0	−3	−1	1	−1	−4	−2	−2	0
mSHMT only
0.5	0	0	0	0	0	0	0	0
0.1	0	0	0	0	0	0	0	0
0	0	0	0	0	0	0	1	0
cSHMT + mSHMT
0.5	−1	0	0	0	−2	−1	0	0
0.1	−3	−1	1	−1	−4	−2	−2	0
0	−4	−1	2	−2	−4	−3	−3	1

¹Cytoplasmic glycine concentration.

²Cytoplasmic serine concentration.