FIG. 6.

Quantitative modeling of ESE. Data (black traces) are the log₁₀ power of a single EEG trace adjusted to baseline EEG power before pilocarpine injection (calculated between the short pink vertical bars). The sharp increase in power is indicative of ESE. Time 0 (black vertical bars) is 60 min after the 1st motor seizure (green vertical bars indicated) and is the time point of the 1st injection of (A) vehicle, (B) diazepam + vehicle 10 min later (2nd gray vertical bar), (C) diazepam + test compound 10 min later (2nd gray vertical bar), or (D) propofol. Overlying the EEG power is the quantitative model of ESE described in Fig. 5. Red vertical bars indicate 1, 3, and 10 h after the initial treatment injection (indicated). Data in each figure are representative of a single animal in each of the treatment categories. Note that baseline was calculated earlier than shown in A. These data show the varying temporal effects of each treatment on ESE. The polynomial allowed combining data from animals within each treatment group for comparisons across treatment groups.