FIG. 2.
Effect of diazepam (DZ, 1 μM) on GABAA,fast sIPSCs in WT and α5-H105R mice. A and B: normalized, averaged sIPSCs, from WT (CTRL τfast 6.4 ms, τslow 23 ms; DZ τfast 7.9 ms, τslow 39 ms) and α5-H105R mice (CTRL τfast 5.5 ms, τslow 26 ms, DZ τfast 6.8 ms, τslow 32 ms). C and D: normalized, averaged sIPSCs derived from the largest 5% of events, from WT (CTRL τfast 6.6 ms, τslow 23 ms; DZ τfast 8.1 ms, τslow 36 ms) and α5-H105R mice (CTRL τfast 6.2 ms, τslow 32 ms, DZ τfast 7.2 ms, τslow 30 ms). Averages were derived from 42–51 events. Deactivation was fitted to biexponential functions (black curves superimposed on gray traces). Scale bar: 5 ms.