. 2009 Mar;64(3):215–221. doi: 10.1590/S1807-59322009000300012

Table 3.

Pharmacokinetic-pharmacodynamic modeling using bispectral index (BIS) values and plasma propofol concentrations in the CABG and OPCAB treatment groups

Sigmidal E_MAX model
	CABG (Mean (95% CI)	OPCAB (Mean (95% CI)
Best-fit values
Emax (minimum BIS value)	30.4 (20.0 to 40.8)	38.0 (32.1 to 43.9)
Baseline (BIS)	93 (86 to 100)	92 (86 to 97)
Hillslope	1.4 (0.8 to 2.1)	3.6 (1.6 to 5.6)
EC50 (mg L⁻¹)	06 (0.4 to 0.8)	0.9 (0.8 to 1.0)
Goodness of fit
R²	0.96	0.95

Emax: concentration of drug required to produce maximum effect; EC50: concentration of drug required to produce 50% of maximum effect; CABG – coronary artery bypass graft surgery; OPCAB – off-pump coronary artery bypass graft surgery