Figure 5.—

Reduction of centromere-proximal heterochromatin renders X chromosomes vulnerable to age-dependent NDJ in ord⁴/ord¹⁰ oocytes The percentage of X chromosome NDJ is shown for aged (shaded bars) and nonaged (open bars) oocytes. Error bars represent 95% confidence intervals. (A) Aging does not increase X chromosome NDJ In(1)dl-49/y;ord^4/10 oocytes (P ≥ 0.0656; N > 790 for each brood). (B) Df(1)bb¹⁵⁸/y;ord^4/10 oocytes exhibit age dependent in all three broods tested (**P = 0.0001, *P = 0.0059; N > 1030 for each brood). The raw data for A and B are presented in supplemental Tables S4 and S5, respectively.