TABLE 2.

Pairwise alignment of Sir1 orthologs and paralogs

	S cer Sir1	S kud Sir1	S bay Sir1	S cas Sir1	S kud Kos1	S bay Kos1	S kud Kos2	S bay Kos2	S bay Kos3	S cas Kos3a	S cas Kos3b	Z rou Kos3
S par Sir1	77	67	61	23	22	22	21	22	23	21	22	23
S mik Sir1	67	63	61	21	23	22	21	22	21	22	22	23
S kud Sir1	63
S bay Sir1	58	66
S cas Sir1	22	24	24
S kud Kos1	22	21	22	23
S bay Kos1	23	21	22	24	65
S kud Kos2	18	20	21	22	21	21
S bay Kos2	22	20	21	21	26	25	62
S bay Kos3	25	19	21	21	22	22	19	20
S bay Kos3a	25	21	23	21	24	20	19	21	37
S cas Kos3b	25	20	23	21	24	21	19	21	37	98
Z rou Kos3	22	21	26	22	21	22	20	21	29	29	26
S cas Kos4	24	23	25	24	26	26	24	23	22	23	23	23

Sequence identity and similarity of Sir1 orthologs and Kos paralogs. All Sir1 family members from S. cerevisiae, S. kudriavzevii, S. bayanus, S. castellii, and Z. rouxii were aligned by BLASTp. Numbers shown represent percentage of identity. Sequences with identity >50% are in boldface type and between 26% and 29% are in italics.