TABLE 1.

ot119 and ot201 specifically affect cog-1 function in the ASER neuron but not in other cell types

	Canonical cog-1 mutant phenotypes
Genotype	% animals with ASER defect (class I Lsy phenotype = ectopic lim-6∷gfp expression)	% animals with VulB2 defect (loss of ceh-2∷gfp expression)	% animals with Egl defecta	% animals with Pvl defectb
Wild type	0 (n > 100)	0 (n = 58)	0 (n = 30)	0 (n = 30)
ot119	63 (n = 36)c	0 (n = 24)	0 (n = 30)	0 (n = 30)
ot201	89 (n = 54)c	0 (n = 27)	0 (n = 30)	0 (n = 30)
sy607d	100 (n = 35)c	90 (n = 20)e	100 (n = 30)f	87 (n = 30)f
ot119/sy607	90 (n = 20)	11 (n = 19)	0 (n = 30)	0 (n = 30)
ot201/sy607	35 (n = 24)	3 (n = 32)	0 (n = 30)	0 (n = 30)

Markers used are otIs114 (lim-6∷gfp) (Chang et al. 2003) and syIs54 (ceh-2∷gfp) (Inoue et al. 2005).

^aDefined as animals with reduced brood size, including the bag-of-worms phenotype.

^bPvl, protruding vulva phenotype.

^cThis phenotype has already been described in Sarin et al. (2007); animals have been newly scored with similar results.

^dsy607 is a strong loss-of-function or null allele of cog-1 that affects its coding region (Palmer et al. 2002).

^eSimilar to results reported by Inoue et al. (2005).

^fSimilar to results reported by Palmer et al. (2002).