TABLE 1.
41 mRNAs altered in steady state level in cells depleted of αCP1 and αCP2
| mRNA name | Accession no. | AFCaversus mocka | AFC versus lamin A/C | Function |
|---|---|---|---|---|
| Down-regulated | ||||
| αCP2, transcript variant 1 | NM_005016 | -7 | -4.5 | mRNA metabolism and expression |
| Strong similarity to αCP2 | I_1903441 | -6.6 | -4.1 | mRNA metabolism and expression |
| αCP1 | NM_006196 | -3.5 | -3.5 | mRNA metabolism and expression |
| Cyclin H (CCNH) | NM_001239 | -5.5 | -3.4 | Regulation of cell cycle |
| Unknown | I_1931775 | -4 | -3 | Unknown |
| αCP2 | I_932189 | -3.2 | -3.2 | mRNA metabolism and expression |
| Chromosome ORF 30 | NM_014145 | -4 | -3 | Unknown |
| Unknown | I_3585116 | -3 | -2.8 | Unknown |
| Fatty acid desaturase 1 (FADS1) | NM_013402 | -3.2 | -2.4 | Fatty acid unsaturation |
| Hypoxia-inducible factor 1α (Hif1α) | I_958733 | -2.1 | -2.9 | Hypoxia |
| Unknown | ENST00000 | -2.9 | -3.1 | Unknown |
| Unknown | THC152941 | -2.4 | -2.5 | Unknown |
| Hypothetical protein FLJ37478 | NM_178557 | -2.3 | -2.5 | Unknown |
| cDNA FLJ10004 clone HEMBA1000076 | AK000866 | -2.5 | -2.2 | Unknown |
| cDNA FLJ90838 clone Y79AA1002129 | AK075319 | -2.5 | -2.1 | Unknown |
| Hypothetical protein FLJ25006 | NM_144610 | -2.3 | -2.2 | Unknown |
| Ras association domain 5 (RASSF5) | NM_031437 | -2.4 | -2.1 | Ras effector |
| Unknown | THC157597 | -2.4 | -2.1 | Unknown |
| Aldo-ketoreductase 7, A2 (AKR7A2) | NM_003689 | -2.5 | -2 | Aldehyde and ketone detoxification |
| cDNA DKFZp547F1714 | AL831830 | -2.1 | -2.2 | Unknown |
| WD repeat SOCS box 2 (WSB2) | NM_018639 | -2.4 | -2 | Unknown |
| Single-stranded DNA-binding protein 4 (SSBP4) | NM_032627 | -2.2 | -2 | Unknown |
| N-Acetylgalactosaminyltransferase (GALNT11) | NM_022087 | -1.9 | -1.7 | Glycosylation of mucins |
| Repressor of estrogen receptor activity (REA) | NM_007273 | -2.1 | -2.1 | Unknown |
| Ribosome-binding protein 1 | I_961859 | -2.2 | -1.9 | Translation and cardiac development |
| FLJ00069 | AK024476 | -2.1 | -2 | Unknown |
| Novel chromosome 22 gene | AL365511 | -2 | -1.9 | Unknown |
| Up-regulated | ||||
| Unknown | THC1570157 | 5.9 | 10.6 | Unknown |
| cDNA FLJ12961 clone NT2RP2005645 | AK023023 | 2.6 | 2.6 | Unknown |
| Angiomotin-like 1 (AMOTL1) | NM_130847 | 2.7 | 2.5 | Control of angiogenesis |
| Phosphoglycerate dehydrogenase (PHGDH) | NM_006623 | 2.2 | 3 | Serine biosynthesis |
| Ubiquitin-conjugating enzyme (UbcH2) | Z29328 | 2.3 | 3.3 | Ubiquitination of cellular substrates |
| mRNA adjacent to integrated HPV16 (INT423) | AJ431620 | 2.5 | 4.4 | Unknown |
| KIAA1541 protein | AB040974 | 3 | 3.8 | Unknown |
| Cytoskeletal tropomysoin isoform (3 kb) | M12127 | 2 | 2.3 | Actin-myosin interaction |
| Phosphotyrosine and phosphoinositides adaptor | NM_014395 | 2.2 | 2.2 | Signal transduction |
| Unknown | XM_209628 | 2.1 | 2.5 | Unknown |
| Unknown | THC1141659 | 2.4 | 2.5 | Unknown |
| cDNA FLJ10656 clone NT2RP2006038 | AK001518 | 2 | 3 | Unknown |
| Hypothetical protein FLJ10656 (P15RS) | NM_018170 | 2.3 | 2.5 | Unknown |
| RNA helicase (RIG-1) | AF038963 | 2.3 | 2.8 | Antiviral signaling |
a
AFC, average -fold change.