TABLE 3.
RT2 Profiler PCR array human cell cycle analysis
| mRNA name | FCaversus mock | FC versus lamin A/C | Function |
|---|---|---|---|
| Down-regulated | |||
| RAD9A | -2.4 | -3 | DNA repair and DNA damage sensor |
| B cell CLL/Lymphoma 1 (BCL1) or cyclin D1 (CCND1) | -3.7 | -3 | Proto-oncogene |
| Cyclin G1 (CCNG1) | -3.5 | -2.6 | G2 phase and G2/M transition control |
| Hypoxanthine guanine phosphoribosyltransferase 1 (HPRT1) | -2.1 | -2 | Enzyme in purine salvage pathway |
| Minichromosome maintenenance 4 (MCM4) | -2 | -2 | S phase and DNA replication |
| Up-regulated | |||
| Distinct subgroup of the Ras family, member 3 (DIRAS3) | 3 | 4.2 | Tumor suppressor |
| Cyclin-dependent kinase inhibitor 1A (CDKN1A) or p21WAF | 3 | 4.1 | Inhibitor of cyclin dependent kinases |
| B cell CLL/lymphoma 2 (BCL2) | 2.8 | 3.9 | Proto-oncogene |
| Proliferating Cell Nuclear Antigen (PCNA) | 3.1 | 3 | DNA polymerase δ auxilliary protein |
| Tumor protein p53 (TP53) | 3.1 | 2.6 | Tumor suppressor |
| G2 and S phase-expressed gene 1 (GTSE1) | 2.1 | 2 | Overexpression induces G2 to M block |
a
FC, -fold change of double knockdown.