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. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: Curr Drug Metab. 2009 Jan;10(1):29–40. doi: 10.2174/138920009787048428

Table 1. Inhibition of Cholesterol α-Glucosyltransferase by Various O-Linked Oligosaccharides. The Concentration of UDP-Glc and Cholesterol was 3.6 μM and 400 μM, Respectively.

Adapted from Lee, H.; Wang, P.; Hoshino, H.; Ito, Y.; Kobayashi, M.; Nakayama, J.; Seeberger, P.H.; Fukuda, M. Glycobiology, 2008, 18(7), 549–558.

O-linked oligosaccharide IC50 (mM)
Galβ1→3GalNAcα1→p-nitrophenol 7.49
GlcNAcβ1
↓
6
Galβ1→3GalNAcα1→p-nitrophenol		 2.21
NeuAcα2→3Galβ1→3GalNAcα1→octyl 1.09
NeuAcα2→3Galβ1→4GlcNAcβ1
↓
6
Galβ1→3GalNAcα1→octyl		 0.75
GlcNAcα1→4Galβ1→4GlcNAcβ1
↓
6
Galβ1→3GalNAcα1→octyl		 0.47