Mean ± SEM primary ICM response of greater sage grouse (GRSG) to capture and chemical injection differs by injection type (ACTH or saline) but not by bird sex. The basal ICM from the first sample available after capture is compared to the mean peak primary ICM for each of the following groups, by t-test: all GRSG (n = 15), P < 0.0001; ACTH (n = 7), P = 0.0003; saline (n = 8), P = 0.0031; males (n = 8), P = 0.0002; and females (n = 7), P = 0.0068. Levene’s test was used to compare the variance of ACTH-injected to saline-injected birds’ primary ICM peak (P = 0.0012). When treatment groups were compared for differences in their mean basal and primary peak, they were not statistically different from one another (ANCOVA, P > 0.05).