Table 2.

Outcome measures at baseline, 6 and 12 months

Primary Outcome Measures
Arterial stiffness – aortic pulse wave velocity (PWV)
Oxidative stress – plasma isoprostanes
Inflammation – plasma pentraxin 3
Secondary Outcome Measures
Arterial stiffness – augmentation index (AIx)
Arterial stiffness – carotid artery intimal medial thickness (CMIT)
Left ventricular overload – central pulse pressure
Vascular function – brachial artery reactivity (BAR)
Oxidative stress – plasma protein carbonyls
Antioxidant status – plasma total antioxidant capacity, - plasma antioxidant enzyme activities
- plasma antioxidant enzyme activities
Inflammation – C reactive protein, IL-6, IL-8, IL-10 and TNF-alpha
Additional blood measures – full blood profile, electrolytes, liver function
- lipid profile
- plasma immunosuppressant levels
- eGFR
Adverse events
Concomitant therapy
Self reported health – SF 36
Physical Activity – items from the Active Australia questionnaire
Nutrition – four day diet diary