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. 2008 Oct 17;364(1513):71–83. doi: 10.1098/rstb.2008.0151

Figure 1.

Figure 1

Survival of mice infected with S. typhimurium. Wild-type (C57BL/6, black circles) mice show 100% survival at 20 days post-infection. On the contrary, KO mice that do not express phox (NADPH-based respiratory burst, light grey circles) or iNOS (NO production, dark grey circles) die during the course of the study. Interestingly, mortality was much more rapid in the phox−/− group (100% mortality at day 5 post-infection) than in the iNOS−/− group (100% mortality at day 19 post-infection). This suggests that respiratory burst precedes the NO response during the acute inflammatory response (adapted from Mastroeni et al. 2000).