Table 2.
Clinico-pathological characteristics and pre-operative plasma levels
| Patient and tumor characteristics | No of patients (%) Total n = 49 |
Plasma CK18-Asp396 (U/l) Median (IQR) | P-value | Total CK18 plasma level (U/l) Median (IQR) | P-value |
|---|---|---|---|---|---|
| Gender | 0.87 | 0.92 | |||
| Male | 31 (63) | 61.1 (41.8–88.2) | 260.5 (174.1–382.8) | ||
| Female | 18 (37) | 50.5 (37.6–110.2) | 252.9 (184.5–352.1) | ||
| Age (median 68 year, range 31–84) | 0.32 | 0.38 | |||
| ≤ median | 25 (51) | 59.1 (15.1–99.0) | 288.6 (181.6–403.5) | ||
| > median | 24 (49) | 55.6 (34.2–74.0) | 232.4 (177.3–328.6) | ||
| Location | 0.63 | 0.25 | |||
| Colon | 38 (78) | 59.4 (40.5–102.8) | 268.6 (199.7–391.1) | ||
| Rectum | 11 (22) | 56.4 (43.3–68.4) | 208.4 (174.1–377.9) | ||
| Dukes' stage | 0.01 | 0.05 | |||
| A/B | 27 (55) | 49.3 (34.2–67.8) | 235.0 (170.5–303.5) | ||
| C/D | 22 (45) | 69.2 (49.7–114.5) | 295.8 (202.3–706.3) | ||
| WHO classification | 0.43 | 0.56 | |||
| Adenocarcinoom | 45 (92) | 59.1 (39.9–82.2) | 265.4 (186.7–378.3) | ||
| Mucinous carcinoom | 4 (8) | 77.8 (48.9–177.7) | 211.2 (172.0–363.1) | ||
| Tumor diameter (median 4.5 cm, range 2–13.5)* | 0.03 | 0.07 | |||
| ≤ median | 24 (55) | 49.1 (31.9–67.7) | 232.4 (174.5–187.7) | ||
| > median | 20 (45) | 64.7 (43.7–133.3) | 287.3 (180.0–657.6) | ||
| Surgery | 0.001 | <0.001 | |||
| Yes, curative resection | 41 (84) | 51.1 (36.5–73.7) | 235.0 (172.3–331.9) | ||
| No, or palliative | 8 (16) | 162.9 (68.8–346.4) | 971.7 (306.1–2290.4) |
Clinico-pathological characteristics and pre-operative CK18-Asp396 and total CK18 plasma levels. P-values were calculated with Kruskal-Wallis and Mann-Whitney tests and P ≤ 0.05 were considered significant, shown in bold. * Some values missing.