Table 4.
Clinico-pathological characteristics and tumor levels
| Patient and tumor characteristics | No of patients (%) Total n = 40 | CK18-Asp396 level (U/mg) Median (IQR) | P-value | Total CK18 level (U/mg) Median (IQR) | P-value | CK18-Asp396/CK18 × 100 Median (IQR) | P-value |
|---|---|---|---|---|---|---|---|
| Gender | 0.94 | 0.67 | 0.96 | ||||
| Male | 26 | 2.1 (0.2–7.7) | 203.0 (64.0–318.2) | 1.9 (0.3–3.7) | |||
| Female | 14 | 1.3 (0.2–10.3) | 159.0 (33.2–273.5) | 1.7 (0.2–3.6) | |||
| Age (median 68 year) | 0.98 | 0.29 | 0.77 | ||||
| ≤ median | 20 | 1.4 (0.3–6.1) | 165.0 (53.0–331.7) | 1.8 (0.5–3.4) | |||
| > median | 20 | 2.2 (0.2–9.7) | 219.1 (57.0–248.9) | 2.2 (0.2–3.8) | |||
| Location | 0.003 | 0.03 | 0.005 | ||||
| Colon | 32 | 0.8 (0.2–5.7) | 147.0 (47.1–243.3) | 1.4 (0.2–2.4) | |||
| Rectum | 8 | 12.7 (3.5–19.5) | 291.5 (214.6–369.7) | 3.7 (2.8–6.3) | |||
| Dukes' stage | 0.79 | 0.49 | 0.90 | ||||
| A/B | 25 | 1.6 (0.3–9.7) | 177.1 (71.8–310.2) | 1.8 (0.2–3.4) | |||
| C/D | 15 | 1.3 (0.1–5.9) | 222.4 (32.7–252.1) | 2.0 (0.4–3.8) | |||
| WHO classification | 0.90 | 0.49 | 0.94 | ||||
| Adenocarcinoom | 37 | 1.6 (0.3–7.7) | 190.3 (56.9–281.9) | 1.9 (0.3–3.4) | |||
| Mucinous carcinoom | 3 | 1.1 | 65.4 | 1.7 | |||
| Tumor diameter (median 4.5 cm)* | 0.37 | 0.43 | 0.31 | ||||
| ≤ median | 20 | 4.3 (0.3–10.3) | 203.0 (56.9–310.2) | 2.3 (0.3–3.9) | |||
| > median | 18 | 1.3 (0.1–5.7) | 154.0 (36.7–281.9) | 1.6 (0.2–2.3) |
Clinico-pathological characteristics and tumor CK18-Asp396, total CK18 and CK18-Asp396/CK18 ratios. P-values were calculated with Kruskall-Wallis and Mann-Whitney tests and P ≤ 0.05 were considered significant, shown in bold. * Some values missing.