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. 2009 Apr 15;4(4):e5264. doi: 10.1371/journal.pone.0005264

Figure 3. Evaluation of gross pathology, radiology and bacterial loads upon infectious challenge.

Figure 3

Individual scores per treatment group and group median values are plotted for macroscopic lung pathology (PA) (A), hilar LN involvement (B), extra-thoracic PA (C), bacterial burden in the lung (D), and chest X-ray (CXR) scores at autopsy (E). Kinetics of TB disease are reflected by mean CXR scores (+standard error of the mean) per treatment group in time (F). BCG/MVA shows protection by significantly reduced lung lesion scores and CXR scores at autopsy compared to non-vaccinated controls, and by reduced hilar LN involvement and CFU in the lung (not significant). SO2 in comparison to non-vaccinated controls shows significant protection by reduced lung lesion scores and delayed kinetics of TB by CXR in time, and by reduced CFU in the lung (not significant). For legends of colouring and symbols see legend to Figure 2. For BCG/MVA treatment CXR at autopsy n = 5; one recording censored due to technical error.