Table 1.

Regional variations in amino acid substitutions among the SLC26A4–6 orthologs

		Protein domain
Gene	Parameters	N-terminus	SulPtp	SUL1′	Charged cluster	STAS	C-terminus	Total
SLC26A4	Domain Sites	1–69	70–517	518–610	611–628	629–733	734–780	1–780
(Pendrin)	% substitutions	12.6 (125/1016)	5.7 (407/7180)	5.6 (84/1513)	7.1 (22/311)	6.3 (101/1601)	10.8 (75/694)	6.6 (814/12315)
	PAML	0.217±0.039	0.102±0.009	0.124±0.019	0.132±0.046	0.105±0.018	0.181±0.039	0.115±0.007
SLC26A5	Domain Sites	1–65	66–503	504–587	588–630	631–723	714–744	1–744
(Prestin)	% substitutions	7.3 (77/1056)	0.5 (39/7497)	2.3 (32/1390)	11.7 (84/718)	5.1 (52/1411)	15.9 (76/477)	3.0 (380/12649)
	PAML	0.120±0.025	0.012±0.003	0.079±0.017	0.179±0.036	0.086±0.021	0.176±0.052	0.048±0.003
SLC26A6	Domain Sites	1–112	113–508	509–630	631–651	652–738	739–759	1–759
(CFEX)	% substitutions	7.8 (139/1774)	12.8 (811/6330)	15.8 (252/1594)	26.5 (89/336)	7.3 (105/1434)	24.7 (88/355)	12.6 (1485/11823)
	PAML	0.288±0.036	0.192±0.015	0.240±0.036	0.783±0.212	0.163±0.029	0.285±0.072	0.234±0.072