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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Ann Epidemiol. 2008 Oct 4;19(1):15–24. doi: 10.1016/j.annepidem.2008.08.009

FIGURE 2.

FIGURE 2

Estimated adjusted hazard ratios (solid lines) with 80% (dark grey) and 95% (light grey) confidence intervals for the association of SUA (in mg/dL) with malignant neoplasms of (a) digestive organs; (b) respiratory system/intrathoracic organs; (c) bone, connective tissue, soft tissue, and skin; (d) genital organs; (e) urinary organs; and (f) lymphoid, hematopoietic and related tissue in 78,850 male VHM&PP participants from REML-optimal extended Cox-type additive hazard regression adjusted for age, BMI, smoking status, occupational status, and year of examination. The effects of SUA on risk of site-specific malignancies were modeled with a penalized spline expansion, with SUA as a time-varying covariate. A SUA concentration of 4.5 mg/dL, as the mid-point of the laboratory reference range, was used as reference value for the calculation of hazard ratios. For abbreviations, see legend to Figure 1.