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. Author manuscript; available in PMC: 2009 Aug 23.
Published in final edited form as: Brain Res. 2008 Dec 24;1256:43–54. doi: 10.1016/j.brainres.2008.12.032

Fig. 1.

Fig. 1

Sox11 is expressed in regenerating peripheral neurons. (A) RNA was collected from L5 DRGs following L5 dorsal root transection and from L4 DRGs following sciatic nerve transection (n =4/group). Sciatic nerve transection induced a 1004% increase in Sox11 mRNA in the L4/L5 DRG 3 d after cut compared to the 51% increase in L5 DRG following L5 rhizotomy. (B) Axotomy of the saphenous nerve caused a 184% increase in Sox11 mRNA in L2/L3 ganglia 3 d after nerve cut. Sox11 remains elevated for at least 7 d with return to baseline by 4 wks. (C) Sox11 immunoreactivity is detected in neuronal nuclei in ipsilateral L4 DRG at 7 d after axotomy of the sciatic nerve. Sox11 immunoreactivity is low in contralateral ganglia (D). *p value<0.001 (A) and <0.05 (B); values are relative to contralateral DRGs. Scale bar in C=50 μm.