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. Author manuscript; available in PMC: 2009 Aug 23.
Published in final edited form as: Brain Res. 2008 Dec 24;1256:43–54. doi: 10.1016/j.brainres.2008.12.032

Fig. 3.

Fig. 3

siRNA injection in crushed saphenous nerve reduces Sox11 mRNA in DRG. (A) At 3 d, nerve crush alone caused a 230% increase in Sox11 in L2/L3 DRGs whereas nerve crush plus PenCON caused a 260% increase. Values are relative to the contralateral DRG where no change in baseline Sox11 mRNA level was measured. PenSOX injection plus nerve crush reduced Sox11 mRNA to 140%. Seven days after crush, a 252% increase in Sox11 was measured while PenCON injected mice had a 225% increase in Sox11. PenSOX siRNA treatment produced a 160% increase in Sox11 that was not statistically different from PenCON values. After 14 days, all experimental conditions had similar levels of Sox11 expression (Sox11: 72% vs 51% vs 45% increase). N=4 per experimental group. (B) Interferon inducible gene mx2 showed no change in expression under all conditions. *p value<0.05.