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. Author manuscript; available in PMC: 2009 Aug 23.
Published in final edited form as: Brain Res. 2008 Dec 24;1256:43–54. doi: 10.1016/j.brainres.2008.12.032

Fig. 6.

Fig. 6

Knockdown of Sox11 modulates ATF3 expression. (A) Cultured DRG neurons transfected with PenSOX targeting siRNA have decreased levels of ATF3 mRNA at 24 h post treatment. (B) Cultured DRG neurons treated with PenCON or PenATF3 siRNAs showed reduction in ATF3 mRNA at 24 h after transfection but no change in Sox11 mRNA. Values are relative to mRNA level at time of dissociation and plating. (C) Transfection of Sox11 siRNAs decreased Sox11 and ATF3 protein in Neuro2a cells. (D) At 3 d after nerve crush ATF3 mRNA in L2/L3 DRGs from untreated and PenCON injected nerves is increased. PenSOX injection plus nerve crush inhibited the rise in ATF3 mRNA. At 7 d and 14 d after injury no difference in ATF3 mRNA level was measured. Values are relative to contralateral side DRG samples. N=3 for all experimental groups. All *p values<0.05. Scale bar in D=40 μm.