TABLE 2.
Characteristics of study participants by UGT1A1 genotype
|
UGT1A1 *1/*1 n=29 (41%) |
UGT1A1 *1/*28 n=36 (51%) |
UGT1A1 *28/*28 n=5 (7%) |
P valuea | |
|---|---|---|---|---|
| Age (yr) | 32 ± 7.16b | 33 ± 5.50 | 31 ± 6.02 | 0.74 |
| Height (m) | 1.7 ± 0.11 | 1.7 ± 0.09 | 1.7 ± 0.14 | 0.79 |
| Weight (kg) | 71.0 ± 15.96 | 68.4 ± 13.86 | 72.74 ± 12.37 | 0.93 |
| BMI (kg/m2) | 20.7 ± 3.8 | 20.1 ± 3.3 | 24.4 ± 2.4 | 0.98 |
| Female (%) | 45% (13) | 55% (20) | 60% (3) | 0.64 |
| Race (%) | ||||
| Caucasian | 48% (14) | 72% (26) | 60% (3) | 0.08 |
| Asian | 48% (14) | 17% (6) | 40% (2) | |
| Other* | 0.03% (1) | 0.11% (4) | 0 | |
| GSTT1/GSTM1 genotype | 0.96 | |||
| (+/+) (46% female) | 12 | 12 | 2 | |
| (−/+) (50% female) | 11 | 17 | 2 | |
| (−/−) (64% female) | 6 | 7 | 1 | |
| Serum Bilirubinc (µmol/L) | ||||
| Total | 14.02 ± 4.96 | 14.02 ± 4.79 | 25.31 ± 9.75 | 0.01 |
| Direct | 1.88 ± 0.68 | 1.88 ± 0.51 | 3.25 ± 1.03 | 0.01 |
| Indirect | 12.14 ± 4.45 | 12.14 ± 4.45 | 22.06 ± 8.89 | 0.02 |
a
Tests for a trend across UGT1A1 genotypes (χ2)
b
Mean ± SD
c
When consuming habitual diets
*
Other includes African Americans and Pacific Islanders