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. Author manuscript; available in PMC: 2010 Apr 15.
Published in final edited form as: J Immunol. 2009 Apr 15;182(8):5098–5106. doi: 10.4049/jimmunol.0803446

Figure 5. AMCase acts anti-apoptotic through a PI3K-mediated pathway.

Figure 5

Levels of phosphorylated Akt (a), Annexin V expression (b) and DNA fragmentation (c) were analyzed in A549 cells treated with increasing doses of AMCase (100ng/ml, 1μg/ml, 10μg/ml and 100μg/ml). Where indicated, the cells underwent serum starvation (left panel) or were treated with FasL (100 ng/ml) (right panel) as described above in detail. Where indicated, PI3K was inhibited using wortmannin (1μM). Data from three independent experiments is shown. * p<0.05, Mann-Whitney U test