(Previously published, Journal of Immunology 176:6523, 2006.) Effects of stroke on cytokines secreted from stimulated splenocytes. Spleens were collected 96 h after vascular occlusion and immune cells were stimulated for 48 h with plate-bound anti-CD3/CD28 antibodies. Supernatants were evaluated for levels of secreted factors, including TNF-α, IFN-γ, IL-6, MCP-1 and IL-10. * Indicates a significant difference in expression in MCAO versus sham MCAO mice.