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Granzyme C is a poor cytotoxin. P815 cells were treated for 1 h with a sublytic concentration of perforin and varying concentrations of gzmC WT (triangles), gzmC E192R/E193G (circles), or human gzmB (squares). Cells were allowed to recover overnight, and survival was measured by MTT assay. EC50 values were determined by fitting a sigmoidal dose–response curve with variable slope.
