Fig. 4.

In vivo adrenal-targeted βarr1 overexpression and aldosterone production in normal rats. (A) Plasma aldosterone levels in AdGFP-, AdGRK2-, or Adβarr1-treated, plus in saline-treated (Saline), normal rats at 7 days post in vivo gene transfer. *, P < 0.05; **, P < 0.01, vs. AdGFP or Saline; n = 5 rats per group. (B) Representative Western blots in protein extracts from adrenal glands from these rats, confirming the overexpression of the respective transgenes. GAPDH is also shown as loading control.