Table 1.
CD8+ cells are essential for survival of tumor bearers
| Mice | % survival after tumor inoculation
|
||
|---|---|---|---|
| 20 days | 40 days | 60 days | |
| TRP-2-treated, B16-bearer control | 100 | 100 | 95 |
| Rat IgG-treated | 100 | 100 | 85 |
| CD4+ cell-depleted | 100 | 95 | 70 |
| CD8+ cell-depleted | 60 | 0 | 0 |
| MUT-1-treated, 3LL-bearer control | 100 | 35 | 0 |
| Rat IgG-treated | 100 | 40 | 0 |
| CD4+ cell-depleted | 95 | 20 | 0 |
| CD8+ cell-depleted | 5 | 0 | 0 |
Ear skin and adbominal skin were tape-stripped 24 hr before application of peptide; the first topical application to ear skin was performed 7 days after tumor inoculation, and the second application was 2 days later to abdominal skin.