Skip to main content
. 2009 Mar 10;106(14):5972–5977. doi: 10.1073/pnas.0806422106

Fig. 1.

Fig. 1.

HRs from AC3-I mice are slower than controls during stress in vivo, but not during rest or ex vivo. (A) HRs recorded in unanesthetized, physically restrained mice during echocardiography. In vivo HRs were significantly (P <0.001) slower in AC3-I mice than in controls (n = 9–12/group). (B and C) HRs recorded from ECG telemetered mice at rest (B) and after ISO injection (C) (0.4 mg/kg i.p.). In vivo HRs were significantly (P <0.05) slower in AC3-I mice compared with controls (n = 4–7/group) after ISO, but not at rest (P = 0.1). (D) Langendorff-perfused hearts from AC3-I and control mice (n = 5–6/group) beat at equivalent rates in the absence of ISO (P = 0.318). (E) ECGs recorded from Langendorff-perfused hearts at baseline and after 1 μM ISO. (F) ISO-HR response relationship in Langendorff-perfused hearts (n = 5–6/group). *, P <0.05 for AC3-I versus control hearts.