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SAN cell CaMKII inhibition reduces ISO rate responses. (A) Example recordings of APs in a WT SAN at baseline (black) and after 100 nM ISO (red). (B) SAN cell AP frequencies in response to a range of ISO concentrations. AC3-I SAN AP frequencies were significantly (*, P <0.05, **, P <0.01, ANOVA) slower than controls at each ISO concentration (n = 6–10 per data point).
