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. 2009 Mar 23;106(14):5865–5870. doi: 10.1073/pnas.0901260106

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Fig. 4. — CvP values indicate the ancestor of the Thermotogales was an extreme thermophile. (A) Distribution of CvP values for predicted proteins of Thermotogales' ancestral proteome. The results of reconstruction with 2 different programs are shown (see Methods). (B) Extrapolation of optimal growth temperature for the ancestral Thermotogales proteome. Red points represent median CvP values and optimal growth temperature of 5 contemporary Thermotogales genomes. A strong linear correlation is observed between CvP values and optimal growth temperature. The median CvP value of the ancestral proteome is based on 423 inferred ancestral protein sequences.