Table 3.
Antiviral potency of C34-Chol and controls against multiple HIV-1 isolates
| HIV isolate | IC50 viral infectivity, pM |
||
|---|---|---|---|
| C34-Chol | C34-Acm | C34 | |
| HXB2 | 8 ± 2 | 227 ± 104 | 141 ± 59 |
| BAL | 9 ± 5 | 344 ± 82 | 273 ± 75 |
| NL4-3 | 6 ± 2 | 173 ± 20 | 292 ± 67 |
| MN-1 | 21 ± 11 | 1,003 ± 184 | 866 ± 367 |
| 89.6 | 34 ± 12 | 6,022 ± 480 | 3,912 ± 1,429 |
| R8 | 15 ± 8 | 516 ± 119 | 314 ± 35 |
| SHIV* | 9 ± 5 | 1,271 ± 301 | 694 ± 353 |
| VSVG† | NA‡ | NA‡ | NA‡ |
The antiviral potency was determined in a single-cycle infectivity assay. All data were from three independent experiments and are expressed as mean ± SEM.
* Strain sf162p3.
†VSVG is a control virus with no HIV envelope.
‡NA, not active.