Table 1.
Iron parameters of mice not treated with phenylhydrazine
| Nramp1+/+, 5 wks | Nramp1−/−, 5 wks | Nramp1+/+, 9 months | Nramp1−/−, 9 months | |
|---|---|---|---|---|
| Hepcidin mRNA, arbitrary units normalized to control | 1 ± 0.09 | 0.063*** ± 0.002 | 0.94 ± 0.04 | 0.057*** ± 0.003 |
| Transferrin saturation, % | 64 ± 7.6 | 84* ± 5.4 | 59 ± 3.6 | 80* ± 1.0 |
| Spleen index | 0.0029 ± 1.4 × 10−5 | 0.0029 ± 1.3 × 10−5 | 0.0026 ± 0.0003 | 0.0046* ± 0.001 |
| Splenic iron content, μg/g wet weight | 953.8 ± 65.81 | 1102.3* ± 58.93 | 1035.8 ± 38.4 | 1265.8* ± 25.2 |
| Liver iron content, μg/g wet weight | 138.6 ± 1.9 | 147.8 ± 5.3 | 154.2 ± 3.9 | 192.4** ± 4.4 |
| Hematocrit, % | 45.3 ± 1.2 | 44.2 ± 3.9 | 44.1 ± 1.4 | 43 ± 1.1 |
| Plasma erythropoietin, mU/ml | 1.48 ± 0.15 | 2.64* ± 0.27 | NA | NA |
| Hepatocyte nonheme iron content, μg per 106 cells | 0.026 ± 0.0014 | 0.017* ± 0.0035 | NA | NA |
*, P ≤ 0.05;
**, P ≤ 0.01;
***, P ≤ 0.0001; n = 6–8. NA, not available.