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. 2009 Mar 16;106(14):5954–5959. doi: 10.1073/pnas.0812782106

Fig. 4.

Fig. 4.

IL-17 mediates neutrophil migration via TNFα, leukotrienes, and CXC chemokines (CXCL1 and CXCL-5). (A and C) Neutrophils harvested from articular cavity 6 h after intra-articular injection of IL-17 (1–30 ng/joint), IL-23 (10 ng/cavity), or saline (Sal, open bars) in mice treated with a co-injection of α-TNFα serum (5 μl/cavity), α-CXCL1 (700 ng/cavity), or α-CXCL5 (700 ng/cavity) antibodies. Some mice also were treated 30 min before with repertaxin (RPTX, 30 mg/kg, s.c.) or 1 h before with MK886 (1 mg/kg, by gavage). (B) Neutrophils harvested from articular cavity 24 h after intra-articular injection of mBSA (10 μg/cavity) or saline in immunized mice (mBSA Im, closed bars) or mBSA (10 μg/cavity) in sham-immunized (Sham-Im, open bar) mice treated with a co-injection of IgG control (α-CTL), α-TNFα serum (5 μl/cavity), α-CXCL1 (700 ng/cavity), or α-CXCL5 (700 ng/cavity) antibodies or 1 h before with MK886 (1 mg/kg, by gavage). *P < 0.05 vs. saline control; #P < 0.05 vs. IL-23, IL-17, or mBSA (immunized) groups. Data are mean ± SEM, n = 5, representative of 3 experiments.