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Analysis of global histone acetylation after TSA treatment and removal. After 0–24 hours of treatment with TSA, total histones were extracted and analyzed on an acid-urea gel. Histones were hyperacetylated after 2 hours of TSA treatment, and hyperacetyaltion peaked at 12–14 hours. Partial deacetylation was observed after 20 and 24 hours of TSA treatment. Removal of TSA (wash) resulted in rapid deacetylation of histones.
