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A significant reduction in hypothermic effect of ethanol (2.0 g/kg) was observed in B6.CB1 -/- (P < 0.001; n = 7-10) and D2.CB1 -/- (P < 0.01; n = 7-10; (A). However, duration of LORR was markedly increased in B6.CB1 -/- (P < 0.05; n = 7-10) and D2.CB1 -/- (P < 0.01; n = 7-10) than +/+ mice (B).
