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The B6.CB1 -/- (P < 0.01) and D2.CB1 -/- mice (P < 0.001) showed a significant reduction in severity of HIC following 8 h after withdrawal from chronic ethanol exposure compared to +/+ mice (A, n = 8-10). Similarly, the CB1 receptor blockade with SR141716A during alcoholization led to a significant reduction in severity of the HIC in regular B6 (P < 0.001) and D2 mice (P < 0.05) compared to vehicle treated mice, respectively (B, n = 8-12). CT-Control; SR-SR141716A.
