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The CB1 receptor-mediated G-protein activation was measured in the crude synaptic membrane isolated from various brain regions of ethanol naïve B6 and D2 mice. The CB1 receptor-mediated G-protein activation was found to be significantly higher (P < 0.05) in the striatum of B6 compared to D2 mice (B). Data presented as percentage over the basal value (n = 5-8 in each group).
