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. Author manuscript; available in PMC: 2010 Feb 3.
Published in final edited form as: Cancer Cell. 2009 Feb 3;15(2):103–113. doi: 10.1016/j.ccr.2009.01.001

Figure 1. IL-6 controls tumor formation and growth in a mouse CAC model.

Figure 1

WT and Il6-/- mice were subjected to AOM-based CAC induction protocol using three cycles of 2.5% (A) or 1.5% (B) DSS in drinking water. Tumors were counted at the end of the 12 week CAC induction regimen. Data represent average tumor numbers ± s.d., n>10. p=0.003 for (A); p=0.0001 for (B). (C) Tumor sizes were determined using imaging Spot software (Zeiss) for microscopic tumors or with a caliper for macroscopic tumors. Average tumor size ± s.d. is shown; * p=0.012. (D) Histogram showing size distribution of tumors. (E) Average tumor load was determined by summing all tumor diameters for a given animal. Results are averages ± s.d. (n>7); * p=0.047.