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. Author manuscript; available in PMC: 2010 Feb 3.
Published in final edited form as: Cancer Cell. 2009 Feb 3;15(2):103–113. doi: 10.1016/j.ccr.2009.01.001

Figure 4. IL-6 regulates cell proliferation and expression of genes involved in proliferation, survival and inflammation.

Figure 4

(A) Colons of adenoma-bearing mice were stained with anti-PCNA antibody. Scale bar- 50 μm. (B) Lysates of distal colons of adenoma-bearing mice were prepared and PCNA mRNA expression was analyzed by Q-RT-PCR. Results are averages ± s.d. (n=3). (C) Sections of adenoma-bearing colons were stained with antibodies to cyclin D. Scale bar- 50 μm. (D) Percentages of Ki-67-positive cells within colonic crypts. Results are averages ± s.d. (n=6), * p=0.005. (E) IEC from mice treated with 2.5% DSS were purified on day 10. Expression of the indicated proteins was analyzed by immunoblotting after gel separation. (F) RegIIIγ and Tff3 mRNA expression was analyzed by Q-RT-PCR. Results are averages ± s.d. (n=3).