Table 2.
Greatest regional brain metabolic activation: interaction effects of strain and diet
| Brain structure | Cluster level (KE)a | Interaction effects | T-value | Z-score | P-value | Stereotaxic location x, y, z (mm) |
|---|---|---|---|---|---|---|
| Right hippocampus | 65 | Le R > Le U | 4.97 | 3.81 | < 0.001 | 1, 11, −2 |
| Ob R < Ob U | ||||||
| Ob R < Le R | ||||||
| Ob U > Le U | ||||||
| Left hippocampus | 65 | Le R > Le U | 4.73 | 3.69 | < 0.001 | −3, 11, 0 |
| Ob R < Ob U | ||||||
| Ob R < Le R | ||||||
| Ob U > Le U | ||||||
| Left superior colliculus/occipital cortex | 65 | Le R > Le U | 4.05 | 3.31 | < 0.001 | −3, 11, −4 |
| Ob R < Ob U | ||||||
| Ob R < Le R | ||||||
| Ob U > Le U |
Abbreviations: Le, lean; Ob, obese; R, restricted; U, unrestricted. Pair-wise comparisons and statistical results of the interactions between the factors strain and diet within the two-way ANOVA model implemented through the SPM2 software package. Stereotaxic location refers to distance (mm) of the specific structure from the ear bar.
a
The three regions above fall within one major cluster.