Figure 5.

Severity of glomerulonephritis in GHR/BP KO mice and their WT littermates. The severity of the glomerulonephritis was scored using the criteria as follows: Glomerulonephritis was graded in the order of increasing severity: Grade 0, no lesions; Grade 1, minimal change in glomeruli (minimal glomerulosclerosis); Grade 2, Grade 1 with a few (less than 10) casts in renal tubules; Grade 3, Grade 1 with more than 10 casts in renal tubules; and Grade 4, Grade 3 with interstitial fibrosis. The average severity of glomerulonephritis in mice from each group is shown (a). *The value was significantly different (p < .05) from that of WT mice. (b) and (c) show the histopathology of kidney in GHR/BP KO (b: Grade 0) and WT (c: Grade 3) mice. GHR/BP = growth hormone receptor/binding protein; KO = knockout; WT = wild type.