Fig. 2.

Longitudinal changes of microbial translocation markers according to African disease progression groups. The last HIV-negative time point for each patient (year 0) and all subsequent years postseroconversion are shown for each progression group [LTNP (circles), SP (inverted triangles), and RP (squares)] for LPS (A), EndoCAb (B), LBP (C), and sCD14 (D). Longitudinal variation in patient levels was determined using linear multilevel modeling fit with slopes in the log scale for each group. The resulting regression line for each group is shown in the respective color. Significant inequality in slopes across groups is indicated where applicable (P < .05).