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. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: Vascul Pharmacol. 2008 Nov 21;50(3-4):89–97. doi: 10.1016/j.vph.2008.11.001

Figure 3.

Figure 3

Caffeine blocks 5-HT elicited cytosolic [Ca2+] increases in PASMCs. (A) 10 μM 5-HT induced Ca2+ transient in the absence then presence of 10 mM caffeine. Agonists were present at times shown by the horizontal bars. Dashed line shows the resting cytosolic [Ca2+]. (B) Dose dependent inhibition of 10 μM 5-HT induced Ca2+ transients by caffeine. Solid line is the resultant dose-response curve fitted to the data with a simple binding equation. Values are means of % peak Ca2+. Error bars represent ± S.E.M for 8 to 10 cells at each concentration of caffeine evaluated.